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Peyote is normally prepared by cutting the mescaline-filled buttons from the plant.

These buttons can be dried and then eaten. They can also be soaked in water to make a psychoactive tea. Some spiritual practitioners consume it in this way.

The buttons can also be ground into a fine powder and then smoked with tobacco or cannabis. This powder is sometimes put in capsules to avoid the bitter taste.

The mescaline can also be drawn out from the plant and made into pills or liquid. Mescaline can also be created synthetically in a lab.

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Mescaline works by increasing the amount of serotonin and dopamine bonded to receptors in the brain. These two neurotransmitters are responsible for feelings of happiness and elation, and in large quantities produce psychedelic effects.

The psychological effects of mescaline include vivid hallucinations.

Users often claim they can “see music” or “hear colors.” They may have visions and altered perceptions of space and time. Colors may appear brighter, sounds more distinct, and vision may feel enhanced.

Users may also feel profound joy or extreme terror and have dramatic emotional experiences. As with LSD, some people may have a negative experience with peyote, also known as a “bad trip.”

Physical effects of peyote often include numbness and tension. It can also cause an increase in blood pressure and heart rate. Users may experience:

• nausea
• elevated body temperature
• chills
• sweating or shivering

Among certain indigenous populations across the Americas, peyote is believed to have medical properties.It’s been said to aid in the treatment of everything from toothaches to diabetes.

In modern medicine, psychedelics are gaining traction as a therapeutic treatment for treatment-resistant depression, but there is little research on their abilities to treat other ailments.

The long-term effects of peyote are also poorly understood.According to the National Institute on Drug Abuse (NIDA)Trusted Source, there’s no link between long-term peyote use and psychological or intellectual disabilities. But frequent users may experience flashbacks.

As with other psychedelics, users may also experience a “comedown,” a period of time while the drug is wearing off during which lower moods or shifting moods may be more common.